Victoza$526
Byetta$816
Wegovy$871
Trulicity$975
Ozempic$992
Rybelsus$995
Zepbound$1,052
Mounjaro$1,077
Saxenda$1,308
Victoza$526
Byetta$816
Wegovy$871
Trulicity$975
Ozempic$992
Rybelsus$995
Zepbound$1,052
Mounjaro$1,077
Saxenda$1,308

Byetta vs Mounjaro

Compare Byetta and Mounjaro on active ingredient, dosing schedule, FDA-approved use and pharmacy acquisition cost.

By Sam Reed · Founder and data leadVerified Feb 11, 2026

Byetta

AstraZeneca

Active ingredient
Exenatide
Form
INJECTION
FDA-approved for
Type 2 diabetes
$816
lowest package, pharmacy acquisition cost

Mounjaro

Eli Lilly

Active ingredient
Tirzepatide
Form
INJECTION, SOLUTION
FDA-approved for
Type 2 diabetes
$1,077
lowest package, pharmacy acquisition cost

The short answer

Byetta contains Exenatide and Mounjaro contains Tirzepatide. These are different molecules, so their dosing and clinical evidence differ.

Side by side

Costs are what a pharmacy pays to acquire each product, from CMS NADAC. Not a retail price, and not what you would pay.

Byetta
Mounjaro
Lowest package cost
$816
$1,077
Active ingredient
Exenatide
Tirzepatide
Manufacturer
AstraZeneca
Eli Lilly
Form
INJECTION
INJECTION, SOLUTION
FDA-approved for
Type 2 diabetes
Type 2 diabetes
= better value on that rowScroll sideways on small screens — the first column stays pinned
Keep comparing
Data sources · cited with retrieval dates
  • CMS NADACNational Average Drug Acquisition Cost, weekly fileretrieved Feb 11, 2026
  • CMS Medicare Part DPrescriber public use file, by geography and drugretrieved Feb 11, 2026
  • CMS State Drug UtilizationQuarterly Medicaid prescription and reimbursement dataretrieved Feb 11, 2026

NADAC figures are pharmacy acquisition costs, not retail prices and not what you will pay. This content is educational and is not medical advice.