Compounded semaglutide vs Zepbound

Compare Compounded semaglutide and Zepbound on active ingredient, dosing schedule, FDA-approved use and pharmacy acquisition cost.

By Sam Reed · Founder and data leadVerified Aug 12, 2026

Compounded semaglutide

Compounded — no single manufacturer

Active ingredient: Semaglutide
Form: —
FDA-approved for: Not an FDA-approved product

Not NADAC-indexed

lowest package, pharmacy acquisition cost

Zepbound

Eli Lilly

Active ingredient: Tirzepatide
Form: INJECTION, SOLUTION
FDA-approved for: Weight management, Obstructive sleep apnea

$1,052

lowest package, pharmacy acquisition cost

The short answer

Compounded semaglutide contains Semaglutide and Zepbound contains Tirzepatide. These are different molecules, so their dosing and clinical evidence differ.

Side by side

Costs are what a pharmacy pays to acquire each product, from CMS NADAC. Not a retail price, and not what you would pay.

Compounded semaglutide

Zepbound

Lowest package cost

Not NADAC-indexed

$1,052

Active ingredient

Semaglutide

Tirzepatide

Manufacturer

Compounded

Eli Lilly

Form

—

INJECTION, SOLUTION

FDA-approved for

Not FDA-approved

Weight management, Obstructive sleep apnea

= better value on that rowScroll sideways on small screens — the first column stays pinned

Keep comparing

Byetta vs Compounded semaglutide Byetta vs Zepbound Compounded liraglutide vs Zepbound

Data sources · cited with retrieval dates

CMS NADACNational Average Drug Acquisition Cost, weekly fileretrieved Aug 12, 2026
CMS Medicare Part DPrescriber public use file, by geography and drugretrieved Aug 12, 2026
CMS State Drug UtilizationQuarterly Medicaid prescription and reimbursement dataretrieved Aug 12, 2026

NADAC figures are pharmacy acquisition costs, not retail prices and not what you will pay. This content is educational and is not medical advice.